• Diptheria and Tetanus vacccine and Guillain-Barre syndrome and brachial neuritis.
• measles vaccine and anaphylaxis.
• oral polio vaccine and Guillain-Barre syndrome
• unconjugated (PRP) Hib vaccine and early-onset Hib disease in children age 18 months or older who receive their first Hib immunization with unconjugated (PRP) vaccine."

• diphtheria and tetanus toxoids and anaphylaxis
• measles vaccine and death from measles vaccine-strain viral infection.
• measles-mumps-rubella vaccine (MMR) and thrombocyopenia and anaphylaxis
• oral polio vaccine and poliomyelitis and death from polio-vaccine-strain viral infection
• hepatitis B vaccine and anaphylaxis."

The Committee also concluded that in about two thirds of the reported suspected cases(p16) " the evidence is inadequate to accept or reject a causual relationship (p12) between

• measles vaccine and encephalopathy, subacute scheerosing panencephalitis, residual seizure disorder, sensorineural deafness (MMR), opic neuritis, transverse myelitis, Guillain-Barre syndrome, thrombocytopenia, Insulin dependent diabetes mellitus.
• mumps vaccine and encephalopathy, aseptic meningitis, sensorneural deafness (MMR), insulin depdent diabetes mellitis, sterility, thrompocytopenia, anaphylaxis
• DT/Td/T vaccine and residual seizure disorder other than infantile spasm, demyelinating diseases of the central nervous system, mononeuropathy, arthritis, erythema multiforme.
• Polio Vaccine (oral OPV or injected IPV) and transverse myelitis (OPV), Guillain-Barre syndrome (IPV), death from SIDS,
• Hepatitis B vaccine and Guillaain-Barre Syndrome, demyelinting diseases of the central nervous system, arthritis, death from SIDS.
• H influensae type b. and Guillain-Barre syndrome, transverse myelitis, thrombocytopenia, anaphylaxis, death from SIDS."

The Committe went on to comment on the lack of controlled studies of adverse reactions and to say "the risk of developing these conditions because of vaccination would seem (their emphasis) to be low." They finally called for "increased surveillance of reports of demyelinating disease and arthritis following hepatitis B vaccination, better follow-up of reports of death and other serious adverse events following vaccination, increased use of large databases (currently used only on a small scale) to supplement passive survelliance reporting sytems and disease registries".

As for safety: "The Commitee encountered many gaps and limitations in knowledge bearing directly and indirectly on the safety of vaccines. These include inadequate understanding of the biologic mechanisms underlying adverse events following natural infection or immunization, insufficient or inconsistent information from case studies and case series, inadequate size or length of follow-up of many population-based epidemiologic studies, and limited capacity of existing surveillance systems of vaccine injuray to provide persuasive evidence of causation.... Clearly, if resarch capacity and accomplishment in these areas are not improved, future reviews of vaccine safety will be similarly handicapped." p 317

They were critical of the safety criteria employed in testing all the commen childhood vaccines.

RISK FACTORS

Even when the Committee found that there was a causual relationship between cases of disease and vaccination, this did not mean that the risk was necessarily high. In most cases they were low - but the Committee totally failed to address the question of viral contamination of vaccines - in particular the established contamination of the polio vaccine with monkey viruses that are now implicated in many thousands of disease cases.

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